Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia
Amanda Lillywhite, Stephen G. Woodhams, Sara Vieira Goncalves, David J.G. Watson, Li Li, James J. Burston, Peter R.W. Gowler, Meritxell Canals, David A. Walsh, Gareth J. Hathway, Victoria Chapman
This study shows that anxiety increases pain in an osteoarthritis model and reduces opioid effectiveness by altering endogenous opioid function.
PAIN Reports · Nov 1, 2021Peer-reviewedNeuroscience