Meritxell Canals

This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.

This study investigates how membrane permeability affects the potency of fentanyl and isotonitazene, finding that fentanyl's extreme potency may be due to its ability to accumulate in membranes and repartition to bind receptors.

The paper investigates whether CCR8 is a high-affinity receptor for CCL18 and finds that CCR8 does not respond to CCL18 in multiple assays.

This study shows that anxiety increases pain in an osteoarthritis model and reduces opioid effectiveness by altering endogenous opioid function.