James J. Burston

Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.

This study shows that anxiety increases pain in an osteoarthritis model and reduces opioid effectiveness by altering endogenous opioid function.