MicrobiologybioRxivPreprint
Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection
Catherine M Kerr, Jessica J Pfannenstiel, Yousef M Alhammad…·Anthony R Fehr
This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.