Better antibodies engineered with a GLIMPSE of human data
N. Lance Hepler, Andrew J. Hill, David B. Jaffe, Michael C. Gibbons, Katherine A. Pfeiffer, David L. Hilton, Melanie Freeman, Wyatt J. McDonnell
GLIMPSE-1, a protein language model trained on human antibody sequences, improves antibody engineering for affinity, cross-reactivity, and developability by leveraging patterns in the human repertoire.
bioRxiv · Jun 8, 2025 · PreprintBioinformatics