Andrew J. Hill

Better antibodies engineered with a GLIMPSE of human data

GLIMPSE-1, a protein language model trained on human antibody sequences, improves antibody engineering for affinity, cross-reactivity, and developability by leveraging patterns in the human repertoire.

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

The paper uses a combined single-cell genetic and chemical screening platform to analyze kinase dependencies in glioblastoma response to targeted therapy, identifying adaptive signaling and potential combination therapies.

crisprQTL mapping as a genome-wide association framework for cellular genetic screens

This paper introduces crisprQTL mapping to identify gene regulation by using CRISPR perturbations and single-cell RNA-seq in human cells, finding 128 cis-regulatory elements affecting nearby genes.

On the design of CRISPR-based single cell molecular screens

The paper identifies a major issue with CRISPR-based single cell screens due to guide-barcode swapping and presents an optimized method to improve accuracy.