David B. Jaffe

GLIMPSE-1, a protein language model trained on human antibody sequences, improves antibody engineering for affinity, cross-reactivity, and developability by leveraging patterns in the human repertoire.

This study uses Linked-Read sequencing to assemble a high-quality, contiguous reference genome for Capsicum annuum, demonstrating its utility for complex plant genomes.

This study identifies the causal mechanism of X-linked Dystonia-Parkinsonism (XDP) by integrating genome and transcriptome assembly, revealing a SVA insertion causing intron retention and TAF1 dysfunction.

This paper combines linked-read sequencing and optical mapping to improve de novo genome assembly for the Hawaiian Monk seal, achieving higher scaffold quality and length than existing methods.