Author

Katherine A. Pfeiffer

10X Genomics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Albert XuiD· 1 shared Andrew J. HilliD· 1 shared Britt AdamsoniD· 1 shared Daniel P. Riordan· 1 shared David B. JaffeiD· 1 shared David L. Hilton· 1 shared Elliott J. Meer· 1 shared Ian T. FiddesiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Albert XuORCID

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2 papers

Recent·Most cited

Better antibodies engineered with a GLIMPSE of human data

N. Lance Hepler, Andrew J. Hill, David B. Jaffe, Michael C. Gibbons, Katherine A. Pfeiffer, David L. Hilton, Melanie Freeman, Wyatt J. McDonnell

GLIMPSE-1, a protein language model trained on human antibody sequences, improves antibody engineering for affinity, cross-reactivity, and developability by leveraging patterns in the human repertoire.

bioRxiv · Jun 8, 2025 · PreprintBioinformatics

Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq

Joseph M. Replogle, Thomas M. Norman, Albert Xu, Jeffrey A. Hussmann, Jin Chen, J. Zachery Cogan, Elliott J. Meer, Jessica M. Terry, Daniel P. Riordan, Niranjan Srinivas, Ian T. Fiddes, Joseph G. Arthur, Luigi J. Alvarado, Katherine A. Pfeiffer, Tarjei Sigurd Mikkelsen, , Britt Adamson

This paper introduces a method to directly capture CRISPR guides in single-cell RNA-sequencing libraries, enhancing Perturb-seq scalability and enabling multi-omic measurements.

Nature Biotechnology · Mar 30, 2020Peer-reviewedGenomics