Ex vivo human tumor slices more accurately predict patient responses to an oncolytic virus than in vivo mouse models
Jose Maldonado, Thomas K. S. Wong, Jia-Shiun Leu, Nourhan Abdelfattah, Han Nhat Tran, David S. Baskin, Robert Rostomily, Nestor F. Esnaola, Kristin Michelle Huntoon, Betty YS Kim, Wen Jiang, Muddassir Syed, Amanda Anderson, Preeti Marie, Alaa Tamim, , Kyuson Yun
This study shows that human tumor slices better predict patient responses to an oncolytic virus than mouse models, highlighting indication-specific efficacy.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology