Resilience and vulnerabilities of tumor cells under purine shortage stress
Jianpeng Yu, Chen Jin, Cheng Su, David Moon, Michael A. Sun, Hong Zhang, Xue Chao Jiang, Fan Zhang, Nomingerel Tserentsoodol, Michelle L. Bowie, Christopher J. Pirozzi, Daniel J. George, Robert Wild, Xia Gao, David M. Ashley, , Jiaoti Huang
This study investigates how cancer cells adapt to purine shortage stress and identifies vulnerabilities in purine metabolism and microtubules as therapeutic targets.
Clinical Cancer Research · Aug 11, 2025Peer-reviewedCancer Biology