APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
Estela Área-Gómez, Delfina Larrea, Marta Pera, Rishi R. Agrawal, David N. Guilfoyle, Leila Pirhaji, Kathleen Shannon, Hirra A. Arain, Archana Ashok, Qiuying Chen, Allissa Dillman, Helen Y. Figueroa, Mark Cookson, Steven S. Gross, Ernest Fraenkel, , Tal Nuriel
The paper investigates how APOE4 affects bioenergetic pathways in specific brain regions of aged mice, finding region-specific differences that may contribute to Alzheimer's disease risk.
Scientific Reports · Mar 9, 2020Peer-reviewedNeuroscience