Qiuying Chen

This study shows that NAD+ replenishment with NR or NRH reduces cardiomyocyte senescence and improves diastolic function in aged male mice but not females.

This study uses fluorescence microscopy and compositional analysis to show that plasma membrane proteins and lipids segregate into protein-rich domains and protein-poor regions, suggesting functional segregation of membrane processes.

This study identifies lipid-mediated ER stress as a driver of muscle dysfunction in mitochondrial myopathies and shows that ceramide inhibition improves symptoms in a mouse model.

This study shows that reducing sAC activity restores pigmentation in OCA models and increases melanin synthesis, suggesting targeting melanosome pH as a therapeutic strategy for OCA and skin cancer risk.

This paper identifies SCoR2 as a denitrosylase that reprograms metabolism to protect the heart after myocardial infarction, showing reduced expression in human cardiomyopathy.

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

This study shows maternal vitamin C deficiency in mice leads to DNA hypermethylation and congenital defects, suggesting VitC supplementation may prevent birth defects.

This study shows that expressing alternative oxidase (AOX) reduces reverse electron transfer and oxidative stress in ischemia-reperfusion brain injury, preserving complex I function and providing neuroprotection.

The paper develops an R package for pixel-by-pixel ratio imaging of metabolite pairs in mass spectrometry imaging, enhancing spatial contrast and revealing new tissue regions and biomarkers.

This study shows PRMT1 promotes leukemogenesis by enhancing glycolysis and reducing fatty acid oxidation in AMKL cells.

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

This paper validates whole genome sequencing on trophectoderm biopsies of preimplantation embryos, showing high accuracy and enabling comprehensive genetic analysis.

The paper introduces a method to specifically detect m6A in mRNA from total RNA samples, addressing biases from mRNA purification protocols.

The paper investigates how APOE4 affects bioenergetic pathways in specific brain regions of aged mice, finding region-specific differences that may contribute to Alzheimer's disease risk.

The paper identifies a subclass of sporadic ALS patients with metabolic defects in trans-sulfuration, characterized by increased cysteine and glutathione synthesis and distinct metabolic responses.

The paper identifies a distinct metabolomic subtype in sporadic ALS patients through metabolite profiling and multi-omics integration, showing increased cysteine metabolism and potential therapeutic targets.