Clade B serpins promote direct basal-to-goblet cell differentiation in airways of patients with chronic obstructive pulmonary disease
Tiffany S. Tufenkjian, Jessica Bailey Blackburn, David Nichols, Ana Vásquez, Ciara M. Shaver, Lorraine B. Ware, Timothy S. Blackwell, Bradley W. Richmond
The paper identifies clade B serpins as drivers of basal-to-goblet cell differentiation in COPD, linking them to goblet cell hyperplasia and inflammatory signaling.
bioRxiv · Sep 22, 2026 · PreprintCell Biology