Massive contractions of Myotonic Dystrophy Type 2-associated CCTG tetranucleotide repeats occur via double strand break repair with distinct requirements for helicases
David Papp, Luis C. Hernandez, Theresa A. Mai, Terrance James Haanen, Meghan A O’Donnell, Ariel T. Duran, Sophia M. Hernandez, Jenni E. Narvanto, Berenice Arguello, Marvin Onwukwe, Kara Kolar, Sergei M. Mirkin, Jane C. Kim
This study investigates the molecular mechanisms of CCTG repeat contractions in DM2 using yeast, showing distinct helicase requirements and chromosomal fragility.
G3 Genes Genomes Genetics · Nov 10, 2023Peer-reviewedGenetics