David S. Karow

Addition of Genetics to Quantitative MRI Facilitates Earlier Prediction of Dementia: A Non-invasive Alternative to Amyloid Measures

This paper develops a model combining polygenic risk scores and quantitative MRI to predict dementia onset up to eight years earlier than traditional methods.

Precision Medicine Advancements Using Whole Genome Sequencing, Noninvasive Whole Body Imaging, and Functional Diagnostics

This study evaluates a precision health platform integrating whole genome sequencing and noninvasive clinical assessments in 1190 healthy participants, identifying significant genetic and phenotypic findings linked to disease risk.

Unsupervised integration of multimodal dataset identifies novel signatures of health and disease

The paper integrates multimodal health data to identify novel biomarker signatures for health and disease, showing better predictive power for diabetes and hypertension than traditional biomarkers.

Precision Medicine Screening Using Whole Genome Sequencing And Advanced Imaging To Identify Disease Risk In Adults

This paper screens adults using whole genome sequencing and imaging to detect age-related chronic disease risks, finding unrecognized diseases in 8% of participants and genomic correlations in 25%.

Personalized genetic assessment of age associated Alzheimers disease risk

This paper develops and validates a polygenic hazard score to predict age-specific Alzheimer's disease risk using genetic data from multiple cohorts.

A genetic risk score to guide age-specific, personalized prostate cancer screening

This paper develops a genetic risk score to personalize prostate cancer screening age based on polygenic hazard scores and validates its predictive power in a separate dataset.