Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed myelinating oligodendrocytes in PLP1 mutant mice
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine‐Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
The paper identifies cytotoxic CNS-associated T cells as drivers of axon degeneration in PLP1 mutant mice through single-cell transcriptomics and functional experiments.
iScience · Apr 19, 2023Peer-reviewedNeuroscience