Loss of cell cycle control renders cells nonresponsive to local extrinsic differentiation cues
Kara L. Cerveny, Ingrid Tower, Dayna B. Lamb, Avery Van Duzer, Hannah Bronstein, Olivia L. Hagen, Máté Varga
The paper shows that mutant cells with cell cycle defects either die or differentiate in wild-type environments, while hyperproliferative cells form tumor-like structures and resist differentiation.
bioRxiv · Jul 30, 2019 · PreprintDevelopmental Biology