A framework integrating multiscale in-silico modeling and experimental data predicts CD33 CAR-NK cytotoxicity across target cell types
Saeed Ahmad, Kun Xing, Marcelo S. F. Pereira, Stephanie Castle, Harshana Rajakaruna, Indrani Nayak, William C. Stewart, Kyle A. Beckwith, Mitchell Stuart Cairo, Meisam Naeimi Kararoudi, Dean A. Lee, Jayajit Das
The paper develops a multiscale computational model to predict CD33 CAR-NK cytotoxicity against various target cells using experimental data and flow cytometry.
Proceedings of the National Academy of Sciences · Jan 30, 2026Peer-reviewedCancer Biology