A Closed Computational - Experimental Loop Identifies Metabolic Collapse at the Root of Macrophage Dysfunction due to Zinc Dyshomeostasis
Sunayana Malla, Deandra R. Smith, A. Peer, Derrick R. Samuelson, Daren L. Knoell, Rajib Saha
This study identifies metabolic collapse due to zinc dyshomeostasis in macrophages, showing succinate and kynurenic acid can restore immune function.
bioRxiv · Jan 11, 2026 · PreprintImmunology