Ultra-high-throughput screening of antimicrobial combination therapies using a two-stage transparent machine learning model
Margaret M. Reuter, Katherine L. Lev, Jon Albo, Harkirat Singh Arora, Nemo Liu, Shenghao Tan, Madeline R. Shay, Debmalya Sarkar, Aaron M. Robida, David H. Sherman, Rudy J. Richardson, Nate Cira, Sriram Chandrasekaran
This paper introduces M2D2, a two-stage ML model that identifies synergistic antimicrobial drug combinations and validates them experimentally against E. coli.
bioRxiv · Nov 25, 2024 · PreprintSystems Biology