David H. Sherman

The paper reports chemoselective halogenation of Premarineosin A, yielding analogs with retained antiplasmodial activity against both sensitive and resistant Plasmodium falciparum strains.

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

This study analyzes the gut microbiome of Passalid beetles, revealing high cellulolytic potential and significant methane production comparable to termites.

The paper designs an engineered biosynthetic pathway in E. coli to produce (+)-brevianamides A and B, achieving a 46% yield with a 92:8 diastereomeric ratio.

This paper introduces M2D2, a two-stage ML model that identifies synergistic antimicrobial drug combinations and validates them experimentally against E. coli.

The paper characterizes the structure of a putative terminal amidation domain in natural product biosynthesis and identifies its potential catalytic role.

This study investigates how polyketide synthase thioesterase domains direct substrate nucleophiles for macrolactone formation by analyzing structural and functional properties of modified TEs.

This study identifies novel secondary metabolites and a metabolic lag during oral dysbiosis recovery, linking them to oral and systemic disease progression.

The paper identifies key residues in an acyltransferase that influence substrate selectivity and demonstrates how swapping structural motifs can alter substrate specificity in polyketide synthases.

DDAP predicts biosynthetic pathways of type I PKS by improving module docking domain ordering and affinity prediction, achieving AUC 0.88 and MRR 0.67.