Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen
Hong Nhung Vu, Matti Valdimarsson, Sara Sigurbjörnsdóttir, Kristín Bergsteinsdóttir, Julien Debbache, Keren Bismuth, Deborah A. Swing, Jón Hallsteinn Hallsson, Lionel Larue, Heinz Arnheiter, Neal G. Copeland, Nancy A. Jenkins, Pétur O. Heidarsson, Eirı́kur Steingrı́msson
The paper identifies a novel regulatory mechanism of MITF through SUMOylation and phosphorylation interactions, revealing how mutations affect melanoma predisposition in a mouse model.
EMBO Reports · Aug 21, 2024Peer-reviewedMolecular Biology