Hong Nhung Vu

Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage

The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.

Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity

This study identifies TFE3 and the non-canonical mTORC1 pathway as regulators of melanoma cell state plasticity, showing MITF suppresses the mesenchymal phenotype by modulating TFE3 expression.

Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

The paper identifies a novel regulatory mechanism of MITF through SUMOylation and phosphorylation interactions, revealing how mutations affect melanoma predisposition in a mouse model.