Identification of Juglone, a "first-in-class" inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast-based high throughput screens
Shradha Suyal, Chinmayee Choudhury, Deepinder Kaur, Anand Kumar Bachhawat
This study identifies juglone as a first-in-class inhibitor of ChaC1 using yeast-based screens, showing it inhibits both ChaC1 and ChaC2 with an IC50 of 8.7 μM through a novel mechanism.
Biochemical Journal · Oct 14, 2024Peer-reviewedBiochemistry