Heterogeneity in the M. tuberculosis β-lactamase inhibition by Sulbactam
Tek Narsingh Malla, Kara A. Zielinski, Luis Aldama, S. Bajt, Denisse Feliz, Brendon Hayes, Mark S. Hunter, Christopher J. Kupitz, Stella Lisova, J. Knoška, Jose Manuel Martin-Garcia, Valerio Mariani, Suraj Pandey, Ishwor Poudyal, Raymond G. Sierra, , Marius Schmidt
The paper uses MISC to study Sulbactam inhibition of M. tuberculosis BlaC, revealing heterogeneity, cooperativity, and conformational changes in atomic detail.
bioRxiv · Dec 6, 2022 · PreprintMolecular Biology