This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

bioRxiv · Jul 16, 2026 · PreprintBiophysics

Heterogeneity in the M. tuberculosis β-lactamase inhibition by Sulbactam

Tek Narsingh Malla, Kara A. Zielinski, Luis Aldama, S. Bajt, Denisse Feliz, Brendon Hayes, Mark S. Hunter, Christopher J. Kupitz, Stella Lisova, J. Knoška, Jose Manuel Martin-Garcia, Valerio Mariani, Suraj Pandey, Ishwor Poudyal, Raymond G. Sierra, , Marius Schmidt

The paper uses MISC to study Sulbactam inhibition of M. tuberculosis BlaC, revealing heterogeneity, cooperativity, and conformational changes in atomic detail.

bioRxiv · Dec 6, 2022 · PreprintMolecular Biology

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Guillaume Tetreau, Michael R. Sawaya, Elke De Zitter, Elena A. Andreeva, Anne‐Sophie Banneville, Natalie A. Schibrowsky, Nicolas Coquelle, Aaron S. Brewster, Marie Luise Grünbein, Gabriela Nass Kovacs, Mark S. Hunter, Marco Kloos, Raymond G. Sierra, Giorgio Schirò, Pei Qiao, , Jacques‐Philippe Colletier

The paper determines the structures of Cry11Aa and Cry11Ba toxins using serial femtosecond crystallography, revealing new insights into their in vivo crystallization patterns and toxicity.

Nature Communications · Jul 28, 2022Peer-reviewedMolecular Biology