Hepatocyte nuclear factor 4-mediated lipotoxicity provokes mitochondrial damage in peroxisome-deficient pex19 mutants
Margret Helene Buelow, Julia Sellin, Christian Wingen, Deniz Senyilmaz, Dominic Gosejacob, Aurelio A Teleman, Michael Hoch
This study identifies Hnf4-mediated lipotoxicity as a mechanism causing mitochondrial damage in pex19 mutants, showing that reducing Hnf4 rescues mitochondrial function and survival.
bioRxiv · Aug 26, 2016Cell Biology