Molecular basis of polyadenylated RNA fate determination in the nucleus
Andrii Bugai, Ulrich Hohmann, Ana Lorenzo, Max Graf, Laura Fin, Jérôme O. Rouvière, László Tirián, Yuhui Dou, Marion Le Rest, Patrik Polák, Dennis Johnsen, Lis Jakobsen, Jens Andersen, Julius Brennecke, Clemens Plaschka, Torben Heick Jensen
The paper identifies a nuclear mechanism that determines the fate of polyadenylated RNAs by distinguishing between functional and non-functional transcripts through the opposing actions of PAXT and TREX-2.
Nature · Jun 17, 2026Peer-reviewedMolecular Biology