Clemens Plaschka

The paper reports the structure of cytoplasmic RNA polymerase II and reveals how factors like Gdown1 and RPAP2 prevent premature transcription factor association during its biogenesis.

The paper identifies a nuclear mechanism that determines the fate of polyadenylated RNAs by distinguishing between functional and non-functional transcripts through the opposing actions of PAXT and TREX-2.

The paper introduces Combi-PAINT, a method for super-resolved mRNA imaging, revealing mRNA ultrastructures and molecular patterns in human cells.

The paper identifies Hcfc1 as a CGI-specific co-activator that bridges transcription factors to TFIID, revealing a promoter-class-specific activation mechanism for CGI promoters.

The paper identifies a homeostatic mechanism called interstasis that co-regulates the dosage of proteins with low complexity domains through RNA-based negative feedback.

This study identifies DDX39/UAP56 as a molecular switch that regulates human mRNA export through TREX and TREX-2 complexes.

This study identifies the role of the SFiNX complex dimerization in enabling co-transcriptional silencing via molecular condensate formation in Drosophila.