Julius Brennecke

The paper identifies a noncanonical retrotransposon transmission mechanism in Drosophila that bypasses the need for viral envelope proteins.

The paper identifies a nuclear mechanism that determines the fate of polyadenylated RNAs by distinguishing between functional and non-functional transcripts through the opposing actions of PAXT and TREX-2.

The paper shows piRNA specificity arises from tissue-specific modules acting on non-specific RNA sampling, with Yb guiding processing in somatic cells and catalytic Argonaute triggering amplification in germline cells.

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

The paper presents a high-quality genome assembly of Drosophila melanogaster ovarian somatic cells to study piRNA biology and transposon control.

The paper shows that antisense transposon insertions into host genes trigger piRNA-mediated immunity in Drosophila by generating chimeric transcripts that initiate silencing.

This study uses cryo-ET to visualize copia retrotransposon structure in Drosophila cells, revealing nuclear clustering and size selection during gametogenesis.

ORFtag enables proteome-scale tagging and functional screening in mammalian cells, identifying known and novel regulators of transcription and post-transcriptional processes.

This study identifies an amino acid change in the HP1 protein Rhino that disrupts its interaction with Kipferl, altering chromatin binding and piRNA profiles in Drosophila.

This study identifies DDX39/UAP56 as a molecular switch that regulates human mRNA export through TREX and TREX-2 complexes.

This study identifies Kipferl as a cofactor that recruits Rhino to piRNA clusters by binding DNA motifs and interacting with Rhino's chromodomain, revealing DNA sequence as a determinant of piRNA source loci.

The paper investigates how selfish toxin-antidote elements evade silencing in C. tropicalis by showing maternal mRNA licenses zygotic expression through counteracting piRNAs.

This paper presents an improved RT-LAMP assay for SARS-CoV-2 detection that is rapid, sensitive, and suitable for both laboratory and home testing.

This paper develops a genetic toolkit for studying piRNA biology in Drosophila melanogaster ovaries using transgenic RNAi and reporter systems.

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

This study identifies the role of the SFiNX complex dimerization in enabling co-transcriptional silencing via molecular condensate formation in Drosophila.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.

This study identifies a heterochromatin-specific RNA export pathway for piRNA precursors in Drosophila, revealing how these transcripts bypass nuclear surveillance for cytoplasmic processing.