Torben Heick Jensen

The paper identifies a nuclear mechanism that determines the fate of polyadenylated RNAs by distinguishing between functional and non-functional transcripts through the opposing actions of PAXT and TREX-2.

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

The paper identifies ZAKα as a sensor that detects mRNA stasis at the ribosomal exit channel through interactions with ribosomal proteins and rRNA.

The paper identifies a kinetic ruler mechanism where Nab2 protein concentration determines mRNA poly(A) tail length through competition between polyadenylation and RNA-binding.

This study presents the cryo-EM structure of the snRNA export complex and shows how PHAX synergistically binds components to facilitate snRNA export.

The paper identifies RNA 3' end tailing mechanisms that protect cells from unadenylated RNA by modifying and removing it through different pathways.

The paper shows mammalian RNA polymerase II can terminate transcription at T-tracts, a mechanism also seen in prokaryotes and RNAPIII, and demonstrates this occurs genome-wide in promoter-proximal regions.

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

The paper identifies dual roles of ZC3H18 in promoting NEXT and antagonizing PAXT to co-activate RNA decay pathways for short substrates.

The paper shows that mRNA deadenylation and decay are globally correlated, but deadenylation is not indispensable for decapping, and decapping can initiate on short pA-tails bound by Pab1.

The paper identifies circZNF827 as a repressor of neuronal differentiation by forming a transcription-inhibitory complex with hnRNP-K/L proteins and modulating NGFR expression.

This study identifies NCBP3 as a component of an alternative CBC complex that interacts with EJC and TREX, supporting mRNA processing and nuclear export.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.

The paper analyzes transcription start sites in D. melanogaster, revealing widespread divergent transcription and relationships between core promoter strength, enhancer potential, and expression levels.

The paper investigates how promoter spacing influences PROMPT expression, stability, and length, revealing a mechanism for generating alternative TSSs in mammalian transcriptomes.

This study identifies pervasive alternative splicing in fission yeast, showing that exon-skipping transcripts are mostly non-functional and degraded by nuclear RNA surveillance.

The paper develops a method to classify human RNAs based on exosome sensitivity and transcription initiation, identifying functional lncRNAs and distinguishing them from unstable transcripts.