It takes two vanilloid ligand bindings per channel to transduce painful capsaicin stimuli
Tingyi “Leo” Liu, Ying Chu, Hao‐Ruei Mei, Dennis S. Chang, Huai-hu Chuang
The paper shows that two vanilloid ligand bindings per TRPV1 channel are sufficient for maximal pain signaling, revealing how TRPV1 integrates pain signals from multiple stimuli.
bioRxiv · Aug 12, 2019 · PreprintMolecular Biology