DLGAP5 promotes vascular cell proliferation and remodeling in pulmonary arterial hypertension
Tapan Dey, Iryna Zhyvylo, Dmitry A. Goncharov, Derek Lin, John R. Greenland, Paul J. Wolters, Delphine A Gomez, Lifeng Jiang, Elena A. Goncharova
This study identifies DLGAP5 as a driver of pulmonary vascular remodeling in PAH by promoting cell proliferation and survival through cyclin A2 and DEPDC1 upregulation and BIM suppression.
bioRxiv · Oct 5, 2026 · PreprintCell Biology