This study identifies DLGAP5 as a driver of pulmonary vascular remodeling in PAH by promoting cell proliferation and survival through cyclin A2 and DEPDC1 upregulation and BIM suppression.

bioRxiv · Oct 5, 2026 · PreprintCell Biology

Lactate dehydrogenase-induced DNA Topoisomerase 1 is a novel regulator of smooth muscle cell proliferation and remodeling in pulmonary arterial hypertension

Lifeng Jiang, Iryna Zhyvylo, Dmitry A. Goncharov, Tapan Dey, Neil J. Kelly, Leyla Teos, Lisa M. Franzi, Aisha Saiyed, Nicholas J. Kenyon, John R. Greenland, Paul J. Wolters, Stephen Y. Chan, Horace Michael DeLisser, Tatiana V. Kudryashova, Elena A. Goncharova

This study identifies LDHA-lactate-induced over-lactylation and TOP1 accumulation as drivers of PASMC hyper-proliferation and PAH, with TOP1 inhibition reversing these effects.

bioRxiv · Nov 10, 2025 · PreprintCell Biology

Non-canonical HIPPO-MST1/2 promotes hyper-proliferation of pulmonary vascular cells through CDC20

Tapan Dey, Iryna Zhyvylo, Lifeng Jiang, Samuel O Olapoju, Andressa Z. Pena, Theodore Avolio, Derek Lin, Dmitry A. Goncharov, John R. Greenland, Paul J. Wolters, Horace Michael DeLisser, Soni Savai Pullamsetti, Tatiana V. Kudryashova, Elena A. Goncharova

The paper shows MST1/2 promotes hyper-proliferation and apoptosis resistance in PAH pulmonary vascular cells by up-regulating CDC20.

American Journal of Respiratory Cell and Molecular Biology · Sep 5, 2025Peer-reviewedCell Biology