Elena A. Goncharova

This study identifies DLGAP5 as a driver of pulmonary vascular remodeling in PAH by promoting cell proliferation and survival through cyclin A2 and DEPDC1 upregulation and BIM suppression.

This study shows that GATA6 deficiency in endothelial cells reduces TLR3-interferon signaling and promotes interferon responses in adjacent smooth muscle cells through paracrine effects.

This study identifies LDHA-lactate-induced over-lactylation and TOP1 accumulation as drivers of PASMC hyper-proliferation and PAH, with TOP1 inhibition reversing these effects.

The paper shows MST1/2 promotes hyper-proliferation and apoptosis resistance in PAH pulmonary vascular cells by up-regulating CDC20.

This study identifies endothelial TLR3 insufficiency as a mechanism underlying SARS-CoV-2-induced lung vascular remodeling and suggests TLR3 agonists as a potential therapeutic strategy.

This study shows TSC2 deficiency in pulmonary vascular smooth muscle cells leads to ECM remodeling, hyper-proliferation, and pulmonary hypertension, which can be reversed by restoring TSC2 function.

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.