Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina P Divekar, Jasmine Buck, Tomasz Wrzesiński, Matthew A. Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J.M. Watson, Simon Richard Carding, Wilfried Haerty, Federica Di Palma, , Tamas Douglas Korcsmaros
The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.
Disease Models & Mechanisms · Jan 1, 2019Peer-reviewedSystems Biology