Simon Richard Carding

Systemically delivered Bacteroides thetaiotaomicron-derived bacterial extracellular vesicles inhibit primary and metastatic melanoma growth

This study shows that Bacteroides thetaiotaomicron-derived extracellular vesicles inhibit melanoma growth via immune activation rather than direct cytotoxicity.

Bifidobacterium pseudocatenulatum extracellular vesicles promote Ly6G+ granulocyte infiltration to inhibit melanoma tumour progression

This paper shows that Bifidobacterium pseudocatenulatum extracellular vesicles reduce melanoma growth by promoting Ly6G+ granulocyte infiltration through TLR2 activation.

Decoding Non-coding SNPs: Systems Genomics Modelling Dissects the Heterogeneity of IBD

The paper models the impact of non-coding SNPs on gene regulatory networks in IBD to stratify patients based on gene dysregulation and therapeutic response.

Extracellular Vesicle-Linked Vitamin B12 Acquisition via Novel Binding Proteins in Bacteroides thetaiotaomicron

This study identifies novel cobalamin-binding proteins in Bacteroides thetaiotaomicron and shows their role in extracellular vesicle-mediated nutrient acquisition.

Proteomic and Metabolomic Profiling of Archaeal Extracellular Vesicles from the Human Gut

This study profiles proteomic and metabolomic features of archaeal extracellular vesicles from the human gut, revealing their structural similarity to bacterial EVs and their potential to modulate immune responses.

Nanopore and Illumina Sequencing Reveal Different Viral Populations from Human Gut Samples

The paper compares Illumina and Oxford Nanopore sequencing for viral genome recovery from human gut samples, finding Illumina better for resolved genomes and hybrid approaches better for diversity.

Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease

This study shows that extracellular vesicles from Bacteroides thetaiotaomicron affect host immune pathways differently in various cell types and disease states, with implications for IBD therapy.

Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches

The paper uses transcriptomics and network analysis to study regulatory networks in Paneth and goblet cell enriched gut organoids, identifying key regulators and their links to inflammatory bowel disease.

A systems genomics approach to uncover patient-specific pathogenic pathways in a complex disease

This paper introduces iSNP, a workflow to identify patient-specific pathogenic pathways in ulcerative colitis by integrating SNP profiles with regulatory networks.

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.

Microbiome-host systems interactions: Protective effects of propionate upon the blood-brain barrier

The paper investigates how propionate, a gut microbial metabolite, interacts with the blood-brain barrier through CD14-dependent and NRF2 signaling pathways, suggesting a new mechanism in the gut-brain axis.

A hierarchical Bayesian framework for understanding the spatiotemporal dynamics of the intestinal epithelium

The paper develops a hierarchical Bayesian framework to model spatiotemporal dynamics of intestinal epithelium proliferation and migration under different conditions, concluding a proliferation-driven model is sufficient for most time-scales.