Alastair J.M. Watson

This paper introduces iSNP, a workflow to identify patient-specific pathogenic pathways in ulcerative colitis by integrating SNP profiles with regulatory networks.

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.

This study investigates how acute and chronic inflammatory cell death affects epithelial cell migration in the intestinal villi using computational models and cell-tracking methods.

The paper develops a hierarchical Bayesian framework to model spatiotemporal dynamics of intestinal epithelium proliferation and migration under different conditions, concluding a proliferation-driven model is sufficient for most time-scales.