Deconstructing natural products to develop synthetic small molecule attachment inhibitors with broad spectrum antiviral activity
Consuelo C Correa-Sierra, Jody Cameron, Seyedeh Nargess Hosseini, Devon J. Schatz, James Donnelly, Chloe M. Murrell, Furkat Mukhtarov, Che C. Colpitts, Frederick G. West, Luis M. Schang
This paper identifies the antiviral moieties in EGCG and develops small molecule inhibitors with broad-spectrum antiviral activity against viruses attaching to glycosaminoglycans or sialylated glycans.
bioRxiv · May 20, 2025 · PreprintMicrobiology