Che C. Colpitts

This study shows that HCV NS5A does not inhibit the PKR-eIF2 pathway, contradicting previous claims and supporting that HCV replicates despite active PKR response.

This study shows that thapsigargin inhibits HCV infection by modulating lipid metabolism, affecting both RNA replication and viral egress through distinct mechanisms.

This study identifies PERK pathway activation as an antiviral mechanism against HCoV-229E and SARS-CoV-2 through chemical modulation of the unfolded protein response.

This paper identifies the antiviral moieties in EGCG and develops small molecule inhibitors with broad-spectrum antiviral activity against viruses attaching to glycosaminoglycans or sialylated glycans.

This study shows sialoglycans promote endosomal, but not cell-surface, entry of SARS-CoV-2 and related sarbecoviruses.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.