MicrobiologybioRxiv
PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.
Binayak Sarkar, Jyotsna Singh, Mohit Yadav…·Rajesh S Gokhale
This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.
DOI 10.7554/elife.103817