Tunneling CARs: Increasing CAR T tumor infiltration through the overexpression of MMP7 and SPP1
Stacey N. Van Pelt, Mark White, Candise L. Tat, Devyn Hooper, Lindsay Jones Talbot, Rohan Fernandes, Cliona M. Rooney, Bilal A. Omer
This study shows that overexpressing MMP7 and SPP1 improves GD2.CART infiltration into solid tumors, leading to better tumor control and survival in a xenograft model.
bioRxiv · Jan 24, 2025 · PreprintImmunology