Editing-independent effects of Adar in Drosophila melanogaster
Khadija Hajji, Damiano Amoruso, Barbora Novakova, Nagraj Sambrani, Deying Yang, Anzer Khan, Vojtěch Bystrý, Alejandro Medaglia-Mata, Domenico Alessandro Silvestris, Ernesto Picardi, Mary A. O’Connell, Liam P. Keegan
This study investigates the effects of Adar in Drosophila melanogaster, showing that overexpression of certain Adar isoforms leads to larval lethality and aberrant immune responses, with partial rescue through epigenetic modulation.
bioRxiv · Sep 13, 2025 · PreprintDevelopmental Biology