Ernesto Picardi

This study identifies PTBP1's role in human neural stem cell fate by showing it can be transferred between cells via tunneling nanotubes and extracellular vesicles, affecting proliferation and differentiation.

The paper identifies an alternative splicing event in PLIN3 that generates a mitochondrial-targeted transcript, PLIN3B, which is unstable and not detectable as endogenous protein.

RNAcentral integrates literature and gene-level data to enhance non-coding RNA sequence analysis and functional understanding.

This study investigates the effects of Adar in Drosophila melanogaster, showing that overexpression of certain Adar isoforms leads to larval lethality and aberrant immune responses, with partial rescue through epigenetic modulation.

The paper investigates ADAR1 isoform-specific editing by analyzing binding and editing patterns in human and mouse cells, revealing that cytoplasmic localization drives editing specificity.

HPC-REDItools improves RNA-editing analysis by enabling faster processing of large datasets using MPI-based parallel computing.

The paper investigates A-to-I RNA editing in SARS-COV-2 using RNAseq data and transcriptome data, finding that A-to-G changes represent genuine RNA editing events mediated by ADAR1.