Reimagining productive chemical space for RNA recognition beyond aromaticity
Lukasz T. Olenginski, Dia Patel, Aleksandra J. Wierzba, Robert Batey
This study shows that aliphatic ligands can bind RNA with high affinity and activity, challenging the notion that aromaticity is essential for RNA recognition.
bioRxiv · Aug 11, 2026 · PreprintBiochemistry