Aleksandra J. Wierzba

This study shows that aliphatic ligands can bind RNA with high affinity and activity, challenging the notion that aromaticity is essential for RNA recognition.

The paper determines crystal structures of the RhoBAST RNA aptamer complexed with fluorophores to elucidate the mechanism of ring-opening fluorescence.

This paper introduces PNA-based linkers to enhance RNA imaging probes by improving binding affinity and specificity, demonstrating significant improvements in RNA visualization in live cells.