Lukasz T. Olenginski

The paper investigates cryptic RNA binding sites in the env8 Cbl riboswitch, showing they are energetically accessible and chemically addressable through base displacement and ligand binding.

This study shows that aliphatic ligands can bind RNA with high affinity and activity, challenging the notion that aromaticity is essential for RNA recognition.

The paper determines crystal structures of the RhoBAST RNA aptamer complexed with fluorophores to elucidate the mechanism of ring-opening fluorescence.