Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans
Jose Cortes-Briones, Juan Urrutia-Gandolfo, P. A. Estévez, Arnab Sengupta, Matthew Basilico, Patrick D. Skosnik, Diane Limoncelli, Deepak Cyril D’Souza, Ismene L. Petrakis, John Harrison Krystal
This study shows ketamine decreases and thiopental increases the EEG power spectrum exponent, reflecting changes in cortical excitatory/inhibitory balance.
bioRxiv · May 12, 2025 · PreprintNeuroscience