John Harrison Krystal

This study identifies genetic risk loci for nightmare frequency and explores its genetic correlations with psychiatric traits.

This paper conducts a large-scale epigenome-wide association study of PTSD in the Million Veteran Program, identifying 272 CpG sites associated with PTSD traits and replicating prior findings.

This study shows human claustrum neurons encode uncertainty and prediction errors during aversive learning, with distinct temporal profiles compared to anterior cingulate cortex.

The paper investigates how amygdala beta bursts influence hippocampal activity during emotional processing in humans, finding they suppress hippocampal firing during negative emotional stimuli.

This study investigates how striatal-mediated habits contribute to behavioral rigidity in PTSD compared to trauma-exposed controls.

This study shows that innate avoidance of heights is refined by noradrenergic signaling and prefrontal cortex experience, without external reinforcement.

This study quantifies brain β-hydroxybutyrate (BHB) and 1,3-butanediol (BD) using J-difference edited 1H-MRS, revealing BD contributes significantly to signals traditionally attributed to BHB.

The paper identifies shared epigenetic and genetic loci between generalized anxiety disorder and COVID-19, implicating neuroimmune pathways in their comorbidity.

The paper examines how childhood maltreatment affects brain structure in 3,711 individuals with MDD and PTSD, finding age- and sex-specific brain morphometric differences.

The paper identifies gene expression changes in brain regions associated with chronic pain, highlighting BLA microglia as a key cell type and finding distinct gene expression patterns compared to other pain-related traits.

This study shows ketamine decreases and thiopental increases the EEG power spectrum exponent, reflecting changes in cortical excitatory/inhibitory balance.

The paper investigates transcriptional signatures of trauma in human brain regions using RNA-seq data from 304 donors, identifying differential vulnerability of cortical and amygdala regions to different trauma types.

The paper records claustrum neurons during human sleep and finds they increase activity and track slow waves during NREM sleep.

This study investigates how ketamine induces distinct whole-brain functional connectivity patterns in individuals and links these patterns to gene expression and behavioral responses.

The paper identifies stress-interactive eQTLs that dysregulate gene expression in the brain under stress, uncovering novel genes linked to brain disorder risk in traumatic stress contexts.

The paper analyzes neural state-trait variations in healthy young adults using resting-state fMRI to identify reproducible co-activation patterns linked to behavioral and cognitive features.

The paper shows spatial and temporal autocorrelation explain network topology measures in rs-fMRI data and how they change with aging and drug treatment.

This study examines how subanesthetic ketamine affects brain metabolism, functional connectivity, and working memory in healthy humans using multimodal fMRI.

This paper classifies PTSD vs. controls using MRI data from multiple sites, finding better performance when distinguishing PTSD from trauma-unexposed controls than trauma-exposed controls, and showing DVAE improves generalizability.

This study identifies norepinephrine as a threat prediction error signal during fear learning, contrasting with dopamine's role in reward prediction.

This study finds smaller total and subregional cerebellar volumes in PTSD compared to controls using a large dataset and advanced parcellation methods.

This paper compares four methods for harmonizing cortical thickness data across multiple sites and finds that ComBat-GAM is most effective in detecting case-control differences and age-related cortical thinning.

This study investigates how disruptions in the excitation-inhibition balance affect decision-making in a cortical circuit model, finding that both elevated and reduced E/I ratios impair decision-making in distinct ways.

The paper integrates transcriptomics with large-scale cortical modeling to simulate LSD's effects on brain function, revealing serotonin-2A receptor-mediated changes in cortical connectivity.

This study examines how PTSD affects neural computations of subjective value under uncertainty using fMRI and a gambling paradigm, finding increased aversion to uncertainty and altered valuation system activity in PTSD patients.

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.

The paper identifies a DNA methylation signature linked to phosphatidylethanol (PEth) that better predicts hazardous alcohol consumption than self-reported data in two populations.

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

The paper uses task-based functional MRI connectomes to predict cognitive phenotypes across psychiatric diseases and shows differences in connectomes by disease category and symptom severity.