Differential utilization of PACAP and glutamate in parabrachial neurons shapes pain and stress
Sudhuman Singh, Sunny Zhihong Jiang, William J. Fortun Rosado, William P. Brancaleone, Diego Castillo Rolon, Hugo A. Tejeda, Lee E. Eiden, Yarimar Carrasquillo
The paper investigates the differential roles of PACAP and glutamate in parabrachial neurons in shaping pain and stress responses, showing distinct effects on injury-induced hypersensitivity and inflammation-induced pain.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience